Skin Beautiful MD Metabolic Cleanse
Designed to be used once daily, over a 2 week period to help support optimal metabolic function. Also helps remove xenobiotics, pollutants and other harmful substances, as well as against remnants of pharmaceutical drugs, excess steroid hormones and more.
Vanilla-Berry Flavor, mix 1 scoop with 8 ounces of water. T
Here is a deep dive into the formula.
In the best of times, the body requires appropriate nutritional support for effective functioning of the liver’s detoxification mechanisms. In the modern era of unavoidable environmental pollution, increased mental and physiological stress, and the degraded nutrient density of the food supply, the body may require supplemental amounts of amino acids, minerals, and other factors essential for healthy detoxification.
Phase I reactions transform toxins and metabolic wastes into forms that are then metabolized by phase II enzymes. Phase I primarily involves cytochrome P450 enzymes, while phase II reactions conjugate the intermediate metabolites into forms that are more water-soluble, thereby facilitating their excretion. All In One Metabolic Cleanse contains an array of nutrients specifically formulated to support both phase I and II processes.
This is crucial, because if phase II reactions are sluggish—perhaps due to insufficiency of key conjugates and cofactors—then the intermediate products of phase I may accumulate and overwhelm the body’s capacity to conjugate and excrete them. This can potentially lead to undesirable health complications, since some intermediate metabolites are more harmful than the initial compounds.
A well-known example of this is the buildup of N-acetyl-p-benzoquinoneimine (NAPQI), which is a metabolite of acetaminophen that depletes glutathione levels and may result in impaired liver function, and, over time, liver failure. Thus, when embarking on any healthy, safe detoxification program, it is imperative to ensure the proper functioning of both phase I and phase II pathways.
Like all enzymes, cytochrome P450 enzymes are proteins, and higher protein diets have been shown to increase the activity of these enzymes, while chronic high-carbohydrate intake may have the opposite effect.2 The 17 grams of organic, non-GMO, low-allergen pea protein in each serving of All In One Metabolic Cleanse ensures a steady supply of the individual amino acids required for effective detoxification—particularly the sulfur-containing amino acids—with no added sugar.
Studies in animals and humans indicate that multiple nutrient deficiencies can depress the function of several enzymatic reactions involved in detoxification. The insufficiency of vitamins A, C, E, B complex, folate, copper, iron, zinc, magnesium, calcium, and more, can have adverse effects on the body’s ability to metabolize harmful compounds. All In One Metabolic Cleanse provides a wide array of nutrients to ensure sufficient levels of these critical enzyme cofactors.
Glutathione & supportive nutrients: Glutathione is well-known as the body’s “master antioxidant.” It is a key component of the detoxification system, acting as an antioxidant as well as participating in conjugation reactions. As a hydrophilic molecule, it also aids in increasing the water-solubility of lipophilic toxins, thus facilitating their excretion. The cycling of glutathione between its oxidized and reduced forms, via glutathione reductase, requires riboflavin, niacin, and vitamins C and E, all of which are present in this formula.
Part of the biochemical action of glutathione is accomplished via the glutathione peroxidase enzyme family (GPx),3 which is dependent on selenium (also included in this product). GPx neutralizes harmful lipid peroxides and also reduces hydrogen peroxide safely to water. Additionally, this formula contains N-acetyl-cysteine – a precursor to glutathione – as well as cysteine and glycine, which are two of the three amino acids that comprise glutathione.
Glucuronidation: The glucuronidation of xenobiotics is one of the primary mechanisms for the detoxification of a host of common pharmaceutical drugs, harmful environmental chemicals, and endogenously synthesized substrates, such as excess estrogen. The resulting metabolites are hydrophilic, rendering them more easily excreted.
Calcium d-glucarate inhibits beta-glucuronidase, a colonic bacterial enzyme capable of de-conjugating glucuronic acid-tagged toxins, which may have the undesirable result of harmful substances being reabsorbed into the body. Elevated beta-glucuronidase activity is associated with increased risk for hormone-dependent cancers, such as breast, prostate, and colon.
Molybdenum oxotransferases: Molybdenum is a required cofactor for a family of enzymes that includes xanthine oxidase and sulfite oxidase. A molybdenum deficiency may impair the body’s ability to metabolize environmental contaminants, such as sulfur dioxide in polluted urban areas, and compounds in several commonly consumed foods, such as caffeine and the sulfites used for color retention and food preservation in wine, dried fruit, vinegar and more.
Antioxidants: Phase I oxidation reactions may generate increased amounts of free radicals. All In One Metabolic Cleanse provides several helpful antioxidant compounds to minimize the potential harm that may result, including vitamins C, E, and A, selenium, green tea extract, glutathione, and a proprietary blend of alkalizing high-antioxidant vegetable and fruit juice powders, including spinach, beet, pomegranate, carrot, and grape. Animal studies indicate that, in addition to their antioxidant function, tea polyphenols and quercetin may have stimulatory effects on select cytochrome P450 enzymes.